Genesis 28:6
When Esau saw that Isaac had blessed Jacob, and sent him away to Padan-aram, to take him a wife from thence; and that as he blessed him he gave him a charge, saying, Thou shalt not take a wife of the daughters of Canaan; When Esau saw that Isaac had blessed Jacob, and sent him away to Padan-aram, to take him a wife from thence; and that as he blessed him he gave him a charge, saying, Thou shalt not take a wife of the daughters of Canaan;
Isaac's blessing of Jacob was joined with sending him away to Padan-aram to take a wife from there, under the charge not to take a wife from the daughters of Canaan. This took place when Jacob was fleeing for his life from his brother Esau as the consequence of his own deceptions, after a past life that had been very faulty. It belongs to the account of the troubled experiences of Esau and Jacob, marked by Jacob's selfish plans, the suffering that followed them, and God's eventual retribution.
The blessing, the sending, and the charge served to guard the channels through which the Promised Seed should come. They stand at the beginning of Jacob's trials and victories, which lead at last to complete change of heart and victory, placing Jacob the supplanter among the Israel of God as Israel, prevailer with God.