Genesis 4:16

And Cain went out from the presence of the LORD, and dwelt in the land of Nod, on the east of Eden.

Genesis 4:16 belongs to the testing of Cain and Abel to see whether they would obey God's requirements, in which Cain cherished rebellion and murmuring against God in contrast to Abel's meek submission, and the sacrificial offerings taught that sin brings death and that people come to God through the promised Redeemer. It belongs to the fourth chapter of Genesis which tells the whole story of Cain as a tiller of the ground and Abel as a keeper of sheep, showing God's provision for the healthful employment of man's physical powers and how departure from His plain commands filled the world with transgression and sin and led to God's destruction of the world in the chapters that follow. The verse locates Cain's dwelling in the land of Nod on the east of Eden, while the Garden of Eden itself remained upon the earth long after man became an outcast, lying to the west of Nod so that the fallen race were long permitted to gaze upon the home of innocence with entrance barred only by watching angels.

Cain's going out from the presence of the Lord was a withdrawal from his father's household after receiving God's curse, casting away the promise of the restored Eden to seek his possessions, enjoyment, and home in the earth under the curse of sin apart and away from God, marking his departure and settlement in Nod east of Eden. After choosing his occupation as a tiller of the soil, he founded a city and called it after the name of his eldest son, and in this he stood at the head of that great class who worship the god of this world, whose descendants became distinguished in mere earthly and material progress but were regardless of God and in opposition to His purposes for man. The verse shows Cain continuing to live after his crimes though he merited the sentence of death, because God in mercy spared the first murderer and granted him opportunity for repentance, which Cain refused, living only to harden his heart, encourage rebellion against divine authority, follow Satan, become a tempter to others, and become the head of a line of bold, abandoned sinners whose example and demoralizing influence corrupted the earth and filled it with violence until it called for its destruction.

God's sparing of Cain presented before the whole universe a lesson bearing on the great controversy, illustrating what would have been the result of permitting the sinner to live on forever in rebellion against God, for God's forbearance only made the wicked more bold and defiant until fifteen centuries later the flood of crime and pollution proved it. It was made manifest that the sentence of death pronounced upon the fallen race for transgression of God's law is both just and merciful because the longer men live in sin the more abandoned they become, so the divine sentence cutting short a career of unbridled iniquity and freeing the world from the influence of those hardened in rebellion is a blessing rather than a curse. Cain's departure illustrates the sinner's state and choice, for though surrounded with the blessings of God's love, the sinner bent on self-indulgence and sinful pleasure desires separation from God above all else, seeking happiness in forgetfulness of God and separation from Him while claiming the good things of God as his by right and taking them as a matter of course with no return of gratitude and no service of love.

Every life centered in self and lived apart from God is squandered, wasting the substance, the precious years, and the powers of mind and heart and soul and working to make itself bankrupt for eternity, and the man who separates from God to serve himself becomes the slave of mammon, with the mind God created for the companionship of angels degraded to earthly and bestial service. The land of Nod east of Eden where Cain fled from God's presence and dwelt identifies the place of Cain's wicked descendants from whom Enoch separated because of their wickedness, and it was there that Enoch later preached God's warning of the coming judgment.