Genesis 4:25
And Adam knew his wife again; and she bare a son, and called his name Seth: For God, said she, hath appointed me another seed instead of Abel, whom Cain slew. And Adam knew his wife again; and she bare a son, and called his name Seth: For God, said she, hath appointed me another seed instead of Abel, whom Cain slew.
Genesis 4:25 belongs to the fourth chapter of Genesis, which tells the whole story of Cain as a tiller of the ground and Abel as a keeper of sheep, and this chapter stands just before the account of God destroying the world because men departed from His plain commands until the world was filled with transgression and sin. The name Seth means appointed or compensation. God gave Adam and Eve another son, Seth, as another seed appointed in place of Abel, whom Cain slew, to be the inheritor of the divine promise and the heir of the spiritual birthright.
Seth was of more noble stature than Cain or Abel and resembled Adam more closely than his other sons, and he was a worthy character who followed in the steps of Abel. Like Cain, he was born in sin with the same sinful, fallen nature inherited from his parents after the fall, with no more natural goodness than Cain, though Adam was created sinless in the likeness of God. By divine grace, through Adam's faithful instruction, and by receiving the knowledge of the Redeemer and instruction in righteousness, Seth served and honored God and did His will.
Seth took Abel's place in doing right and continued the work Abel would have done had he lived, laboring to turn the minds of sinful men to revere and obey God their Creator. He separated himself from Cain's corrupt descendants. His descendants are distinguished from Cain's descendants as those who preserved the knowledge of God's will, though they later turned from God by marrying among Cain's idolatrous descendants.
Seth was the father of Enos, in whose time men began to call upon the name of Jehovah. This was not the beginning of worship, for the faithful had worshiped God before. But as men increased it became an open profession of loyalty to God by one class, made distinct from the contempt and disobedience of the other class.