Genesis 4:26
And to Seth, to him also there was born a son; and he called his name Enos: then began men to call upon the name of the LORD. And to Seth, to him also there was born a son; and he called his name Enos: then began men to call upon the name of the LORD.
Genesis 4:1-26 closes the whole account of life and work after the fall, with Abel as a keeper of sheep and Cain as a tiller of the ground, while the chapters that follow show that departure from plain divine commands filled the world with transgression and sin until God destroyed it. Seth stands as Abel's successor in right-doing, yet like Cain he inherited Adam's sinful nature and was born in sin, having no natural goodness that Cain lacked. Seth was more noble in stature than Cain or Abel and resembled Adam more than his other sons. Through God's grace and Adam's faithful instruction Seth honored the Lord by choosing to do His will.
Seth and his descendants separated themselves from Cain's corrupt and wicked descendants, dwelling apart in mountain homes to preserve themselves from prevailing wickedness and idolatry while cherishing the knowledge of God's will. Seth worked to turn sinful people to revere and obey God. With the birth of Enos to Seth, calling upon the name of the Lord became an open, public profession of loyalty to God, not the beginning of worship itself, since the faithful had worshiped God before this time. The verse marks the rise of a distinct faithful party in a degenerate age when the world was neither all corruption nor all fidelity, and as men increased the distinction between the two classes became more marked, with one class openly professing loyalty to God and the other openly showing contempt and disobedience.
The descendants of Seth stood out as worshipers who called themselves the sons of God, acknowledging the power and government and right of the living God to govern, in contrast to the sons of men descended from Cain who were set against the worship of God. The faithful offered the sacrificial offerings that represented the Lamb of God to take away the sins of the world, while Cain's line despised those offerings. As their numbers grew, Seth's descendants abandoned God by marrying women from Cain's idolatrous descendants.