Isaiah 43:22

But thou hast not called upon me, O Jacob; but thou hast been weary of me, O Israel.

But thou hast not called upon me, O Jacob, is a charge that Jacob and Israel have not called upon God but have grown weary of Him, having stopped calling upon Him. The verse stands in Isaiah 41-45 and its surrounding chapters, where God's purpose for Israel and His people is fully revealed, passages to be prayerfully studied.

Its setting is a redemptive appeal in which, though His people have sinned, He has redeemed them and blotted out their transgressions as a thick cloud for His own sake, calls them to return to Him, will not forget them as His servants, and will glorify Himself in them. They are to look unto Him and be saved, for He is God and there is none else, and in the Lord alone are righteousness and strength, justification and glory.

Growing weary of God means turning away from His wisdom to look to finite man for wisdom, failing to bring Him honor in worship and service while wearying Him with sins and iniquities, thus misusing and dishonoring Him. It pictures a spirit that feels competent to order and dictate and rule others as with a rod of iron. The charge is aggravated because Israel was His own people receiving His care, yet even the animals benefited from His provision and honored Him.

The verse is an earnest appeal showing God's tender concern for His wayward people even when they turn from Him, urging them to remember He has not forgotten them. Its chapter is rich in promises and assurance offered as encouragement amid coming judgments, so that fulfilling its words places people where the Lord will do what He has promised. The verse belongs to prophecies about God's people in the last days when His law is made void, which will be fulfilled. Its section foretells the work of presenting a warning message and giving knowledge of the truth to awaken people to how far they have departed from the Lord's ordinances and transgressed God's law.

The verse therefore calls the Lord's people to earnest repentance and diligent work. They are to seek wisdom from God rather than from finite people, to hide self in Jesus, to walk humbly with God in a deep and living experience with communication kept open between God and the soul, so the Lord is sun and shield.