Jeremiah 44:22
So that the LORD could no longer bear, because of the evil of your doings, and because of the abominations which ye have committed; therefore is your land a desolation, and an astonishment, and a curse, without an inhabitant, as at this day.
The verse belongs to the section of Jeremiah covering the history of the two years before Jerusalem fell. It is part of the account of the Jews left after Zedekiah's captivity and their flight to Egypt, where many turned to idolatry. The land became a desolation, and an astonishment, and a curse, without an inhabitant, because the people persisted in evil and idolatrous practices until the Lord could no longer bear their conduct. The evil involved worship of the queen of heaven, and refusal to heed God's warning and turning to sun worship while disregarding the Sabbath brought desolation and led to Jerusalem's destruction. It shows the sad result of false worship and false education among the people and kings of Judah, and because of the evil of their doings and the abominations of their idolatrous feasts judgment came as the fruit of their evil sowing in captivity and enforced exile, with Zion left in utter ruin.
With its context the verse marks the close of the reign of Josiah in B.C. 607 as the end of the Jewish jubilees, since Josiah was the last king of Jerusalem who obeyed the commandments and kept the statutes. Afterward neither kings, nor nobles, nor people, nor lands could be redeemed, so no year of release or jubilee could be kept, with no more than 21 jubilees having been kept and 23 still lacking to the great jubilee. That date begins the 2450 years of the jubilee of jubilees, reckoned as 49 times 50 years, which reaches to A.D. 1843, when the trumpet of jubilee proclaims liberty and the people of God come into the purchased possession.