Luke 22:11

And ye shall say unto the goodman of the house, The Master saith unto thee, Where is the guestchamber, where I shall eat the passover with my disciples?

Jesus sent Peter and John, who had been chosen to labor closely together, to prepare the Passover meal in Jerusalem. At the yearly feast residents of Jerusalem freely gave rooms to visitors to keep the Passover, in keeping with the custom of accommodating strangers who desired to celebrate it. On entering the city they were to meet a man carrying a pitcher of water in the street and follow him into the house he entered.

To the goodman or householder of that house they were to ask where the guest room was where Jesus would eat the Passover with His disciples. The message was put in the form of a command, which might seem unbecoming for two Galileans to speak to a stranger, yet it met ready assent and happened exactly as foretold. The secret, foretold sign and command guarded against premature movements by traitors coming to the supper to reciprocate the action designed by Judas.

The householder would show them a large upper room furnished for their needs, where they were to make preparations. The meal took place before Jesus suffered, with the disciples alone with Him, and though such feasts were usually joyful, He was troubled because He was about to suffer. That Passover meal became the setting for establishing the Lord's Supper and the foot-washing ordinance, with the Passover giving way to the Lord's Supper as a memorial of His death for His church.

The guest chamber in Jerusalem was the upper chamber where He spent the last night before His death, and the disciples later gathered in that same room after His death in mourning and then hearing reports of His resurrection. After eating that meal with His disciples, Jesus went with them to Gethsemane, a garden where He often prayed.